γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from two Phase I clinical trials of SJG-136 (SG2000)

PURPOSE: To evaluate γ-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs. EXPERIMENTAL DESIGN: γ-H2AX foci formation was validated pre-clinically in comparison to the comet assay, and evaluated pharmacodynamically in two Phase I studies of different...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Wu, Jenny, Clingen, Peter H, Spanswick, Victoria J, Mellinas-Gomez, Maria, Meyer, Tim, Puzanov, Igor, Jodrell, Duncan, Hochhauser, Daniel, Hartley, John A
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485439/
https://ncbi.nlm.nih.gov/pubmed/23251007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2529
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados