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γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from two Phase I clinical trials of SJG-136 (SG2000)

PURPOSE: To evaluate γ-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs. EXPERIMENTAL DESIGN: γ-H2AX foci formation was validated pre-clinically in comparison to the comet assay, and evaluated pharmacodynamically in two Phase I studies of different...

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Publicado en:Clin Cancer Res
Autores principales: Wu, Jenny, Clingen, Peter H, Spanswick, Victoria J, Mellinas-Gomez, Maria, Meyer, Tim, Puzanov, Igor, Jodrell, Duncan, Hochhauser, Daniel, Hartley, John A
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485439/
https://ncbi.nlm.nih.gov/pubmed/23251007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2529
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