Organoid single cell profiling identifies a transcriptional signature of glomerular disease

Podocyte injury is central to many forms of kidney disease, but transcriptional signatures reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo. Human kidney organoids derived from pluripotent stem cells (PSCs), a potentially new model for disease and regeneratio...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Harder, Jennifer L., Menon, Rajasree, Otto, Edgar A., Zhou, Jian, Eddy, Sean, Wys, Noel L., O’Connor, Christopher, Luo, Jinghui, Nair, Viji, Cebrian, Cristina, Spence, Jason R., Bitzer, Markus, Troyanskaya, Olga G., Hodgin, Jeffrey B., Wiggins, Roger C., Freedman, Benjamin S., Kretzler, Matthias
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485369/
https://ncbi.nlm.nih.gov/pubmed/30626756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122697
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