Organoid single cell profiling identifies a transcriptional signature of glomerular disease

Podocyte injury is central to many forms of kidney disease, but transcriptional signatures reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo. Human kidney organoids derived from pluripotent stem cells (PSCs), a potentially new model for disease and regeneratio...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Harder, Jennifer L., Menon, Rajasree, Otto, Edgar A., Zhou, Jian, Eddy, Sean, Wys, Noel L., O’Connor, Christopher, Luo, Jinghui, Nair, Viji, Cebrian, Cristina, Spence, Jason R., Bitzer, Markus, Troyanskaya, Olga G., Hodgin, Jeffrey B., Wiggins, Roger C., Freedman, Benjamin S., Kretzler, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485369/
https://ncbi.nlm.nih.gov/pubmed/30626756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122697
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