Organoid single cell profiling identifies a transcriptional signature of glomerular disease

Podocyte injury is central to many forms of kidney disease, but transcriptional signatures reflecting podocyte injury and compensation mechanisms are challenging to analyze in vivo. Human kidney organoids derived from pluripotent stem cells (PSCs), a potentially new model for disease and regeneratio...

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Publicado en:JCI Insight
Main Authors: Harder, Jennifer L., Menon, Rajasree, Otto, Edgar A., Zhou, Jian, Eddy, Sean, Wys, Noel L., O’Connor, Christopher, Luo, Jinghui, Nair, Viji, Cebrian, Cristina, Spence, Jason R., Bitzer, Markus, Troyanskaya, Olga G., Hodgin, Jeffrey B., Wiggins, Roger C., Freedman, Benjamin S., Kretzler, Matthias
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485369/
https://ncbi.nlm.nih.gov/pubmed/30626756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122697
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