Hypertension induces glomerulosclerosis in phospholipase C-ε1 deficiency

Loss-of-function mutations in phospholipase C-ε1 (PLCE1) have been detected in patients with nephrotic syndrome, but other family members with the same mutation were asymptomatic, suggesting additional stressor are required to cause the full phenotype. Consistent with these observations, we determin...

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Vydáno v:Am J Physiol Renal Physiol
Hlavní autoři: Atchison, Douglas K., O’Connor, Christopher L., Menon, Rajasree, Otto, Edgar A., Ganesh, Santhi K., Wiggins, Roger C., Smrcka, Alan V., Bitzer, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294338/
https://ncbi.nlm.nih.gov/pubmed/32223311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00541.2019
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