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Hypertension induces glomerulosclerosis in phospholipase C-ε1 deficiency

Loss-of-function mutations in phospholipase C-ε1 (PLCE1) have been detected in patients with nephrotic syndrome, but other family members with the same mutation were asymptomatic, suggesting additional stressor are required to cause the full phenotype. Consistent with these observations, we determin...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Atchison, Douglas K., O’Connor, Christopher L., Menon, Rajasree, Otto, Edgar A., Ganesh, Santhi K., Wiggins, Roger C., Smrcka, Alan V., Bitzer, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294338/
https://ncbi.nlm.nih.gov/pubmed/32223311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00541.2019
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