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Structure–Function Analysis of the Extended Conformation of a Polyketide Synthase Module

Catalytic modules of assembly-line polyketide synthases (PKSs) have previously been observed in two very different conformations—an “extended” architecture and an “arch-shaped” architecture—although the catalytic relevance of neither has been directly established. By the use of a fully human naïve a...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Li, Xiuyuan, Sevillano, Natalia, La Greca, Florencia, Deis, Lindsay, Liu, Yu-Chen, Deller, Marc C., Mathews, Irimpan I., Matsui, Tsutomu, Cane, David E., Craik, Charles S., Khosla, Chaitan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484869/
https://ncbi.nlm.nih.gov/pubmed/29762030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02100
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