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Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

In acute myeloid leukemia (AML), acquired genetic aberrations carry prognostic implications and guide therapeutic decisions. Clinical algorithms have been improved by the incorporation of novel aberrations. Here, we report the presence and functional characterization of mutations in the transcriptio...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Jutzi, Jonas Samuel, Basu, Titiksha, Pellmann, Maximilian, Kaiser, Sandra, Steinemann, Doris, Sanders, Mathijs A., Hinai, Adil S. A., Zeilemaker, Annelieke, Bojtine Kovacs, Sarolta, Koellerer, Christoph, Ostendorp, Jenny, Aumann, Konrad, Wang, Wei, Raffoux, Emmanuel, Cassinat, Bruno, Bullinger, Lars, Schlegelberger, Brigitte, Valk, Peter J. M., Pahl, Heike Luise
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484461/
https://ncbi.nlm.nih.gov/pubmed/30755419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-875047
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