A protein quality control pathway regulated by linear ubiquitination

Neurodegenerative diseases are characterized by the accumulation of misfolded proteins in the brain. Insights into protein quality control mechanisms to prevent neuronal dysfunction and cell death are crucial in developing causal therapies. Here, we report that various disease‐associated protein agg...

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Publicat a:EMBO J
Autors principals: van Well, Eva M, Bader, Verian, Patra, Maria, Sánchez‐Vicente, Ana, Meschede, Jens, Furthmann, Nikolas, Schnack, Cathrin, Blusch, Alina, Longworth, Joseph, Petrasch‐Parwez, Elisabeth, Mori, Kohji, Arzberger, Thomas, Trümbach, Dietrich, Angersbach, Lena, Showkat, Cathrin, Sehr, Dominik A, Berlemann, Lena A, Goldmann, Petra, Clement, Albrecht M, Behl, Christian, Woerner, Andreas C, Saft, Carsten, Wurst, Wolfgang, Haass, Christian, Ellrichmann, Gisa, Gold, Ralf, Dittmar, Gunnar, Hipp, Mark S, Hartl, F Ulrich, Tatzelt, Jörg, Winklhofer, Konstanze F
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484417/
https://ncbi.nlm.nih.gov/pubmed/30886048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100730
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