TRAF6 directs FOXP3 localization and facilitates regulatory T‐cell function through K63‐linked ubiquitination

Regulatory T cells (Tregs) are crucial mediators of immune control. The characteristic gene expression and suppressive functions of Tregs depend considerably on the stable expression and activity of the transcription factor FOXP3. Transcriptional regulation of the Foxp3 gene has been studied in dept...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Ni, Xuhao, Kou, Wei, Gu, Jian, Wei, Ping, Wu, Xiao, Peng, Hao, Tao, Jinhui, Yan, Wei, Yang, Xiaoping, Lebid, Andriana, Park, Benjamin V, Chen, Zuojia, Tian, Yizhu, Fu, Juan, Newman, Stephanie, Wang, Xiaoming, Shen, Hongbin, Li, Bin, Blazar, Bruce R., Wang, Xuehao, Barbi, Joseph, Pan, Fan, Lu, Ling
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484404/
https://ncbi.nlm.nih.gov/pubmed/30886050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899766
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