Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats member 13) prevents microvascular thrombosis by cleaving von Willebrand factor (VWF) within platelet-rich thrombi, and cleavage depends on allosteric activation of ADAMTS13 by the substrate VWF. Human...

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Vydáno v:Blood
Hlavní autoři: Muia, Joshua, Zhu, Jian, Greco, Suellen C., Vanhoorelbeke, Karen, Gupta, Garima, Westfield, Lisa A., Sadler, J. Evan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484387/
https://ncbi.nlm.nih.gov/pubmed/30700419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-11-886275
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