Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Store-operated Ca(2+) entry (SOCE) is a ubiquitous pathway for Ca(2+) influx across the plasma membrane (PM). SOCE is mediated by the endoplasmic reticulum (ER)-associated Ca(2+)-sensing proteins stromal interaction molecule 1 (STIM1) and STIM2, which transition into an active conformation in respon...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Emrich, Scott M., Yoast, Ryan E., Xin, Ping, Zhang, Xuexin, Pathak, Trayambak, Nwokonko, Robert, Gueguinou, Maxime F., Subedi, Krishna P., Zhou, Yandong, Ambudkar, Indu S., Hempel, Nadine, Machaca, Khaled, Gill, Donald L., Trebak, Mohamed
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484143/
https://ncbi.nlm.nih.gov/pubmed/30824535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006801
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