Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A

The kinesin-3 family member KIF1A plays a critical role in site-specific neuronal cargo delivery during axonal transport. KIF1A cargo is mislocalized in many neurodegenerative diseases, indicating that KIF1A's highly efficient, superprocessive motility along axonal microtubules needs to be tigh...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Lessard, Dominique V., Zinder, Oraya J., Hotta, Takashi, Verhey, Kristen J., Ohi, Ryoma, Berger, Christopher L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484136/
https://ncbi.nlm.nih.gov/pubmed/30770469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005765
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