Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors

T cell suppression contributes to immune dysfunction in sepsis. However, the underlying mechanisms are not well-defined. Here, we show that exposure of human peripheral blood mononuclear cells to bacterial lipopolysaccharide (LPS) can rapidly and dose-dependently suppress interleukin-2 (IL-2) produc...

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Vydáno v:J Biol Chem
Hlavní autoři: Sueyoshi, Koichiro, Ledderose, Carola, Shen, Yong, Lee, Albert H., Shapiro, Nathan I., Junger, Wolfgang G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484120/
https://ncbi.nlm.nih.gov/pubmed/30787105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007188
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