Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling

T cells play a central role in host defense. ATP release and autocrine feedback via purinergic receptors has been shown to regulate T cell function. However, the sources of the ATP that drives this process are not known. We found that stimulation of T cells triggers a spike in cellular ATP productio...

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Bibliografske podrobnosti
Main Authors: Ledderose, Carola, Bao, Yi, Lidicky, Markus, Zipperle, Johannes, Li, Linglin, Strasser, Katharina, Shapiro, Nathan I., Junger, Wolfgang G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4162192/
https://ncbi.nlm.nih.gov/pubmed/25070895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575308
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