Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense

T cell suppression in sepsis is a well-known phenomenon; however, the underlying mechanisms are not fully understood. Previous studies have shown that T cell stimulation up-regulates mitochondrial adenosine triphosphate (ATP) production to fuel purinergic signaling mechanisms necessary for adequate...

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Veröffentlicht in:J Infect Dis
Hauptverfasser: Ledderose, Carola, Bao, Yi, Ledderose, Stephan, Woehrle, Tobias, Heinisch, Maria, Yip, Linda, Zhang, Jingping, Robson, Simon C., Shapiro, Nathan I., Junger, Wolfgang G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704665/
https://ncbi.nlm.nih.gov/pubmed/26150546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv373
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