Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation

Previous studies have shown that T cell receptor (TCR) and CD28 coreceptor stimulation involves rapid ATP release, autocrine purinergic feedback via P2X receptors, and mitochondrial ATP synthesis that promote T cell activation. Here, we show that ADP formation and autocrine stimulation of P2Y1 recep...

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Veröffentlicht in:Purinergic Signal
Hauptverfasser: Woehrle, Tobias, Ledderose, Carola, Rink, Jessica, Slubowski, Christian, Junger, Wolfgang G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635541/
https://ncbi.nlm.nih.gov/pubmed/30919205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-019-09653-6
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