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Mitochondria Regulate Neutrophil Activation by Generating ATP for Autocrine Purinergic Signaling
Polymorphonuclear neutrophils (PMNs) form the first line of defense against invading microorganisms. We have shown previously that ATP release and autocrine purinergic signaling via P2Y(2) receptors are essential for PMN activation. Here we show that mitochondria provide the ATP that initiates PMN a...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175322/ https://ncbi.nlm.nih.gov/pubmed/25104353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572495 |
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