ATP release is required for Toll-like receptor-induced monocyte/macrophage activation, NLRP3 inflammasome signaling, IL-1β production, and the host immune response to infection

OBJECTIVE: Monocytes and macrophages produce interleukin-1β (IL-1β) by inflammasome activation which involves ATP release, pannexin-1 (panx1) channels, and P2X7 receptors. However, IL-1β can also be produced in an inflammasome-independent fashion. Here we studied if this mechanism also involves ATP...

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Bibliographic Details
Published in:Crit Care Med
Main Authors: Lee, Albert H., Ledderose, Carola, Xiaoou, Li, Slubowski, Christian J., Sueyoshi, Koichiro, Staudenmaier, Laura, Bao, Yi, Zhang, Jingping, Junger, Wolfgang G.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239954/
https://ncbi.nlm.nih.gov/pubmed/30247270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000003446
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