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The endoplasmic reticulum (ER) chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation

Hsp70 and Hsp90 chaperones are critical for protein quality control in the cytosol, whereas organelle-specific Hsp70/Hsp90 paralogs provide similar protection for mitochondria and the endoplasmic reticulum (ER). Cytosolic Hsp70/Hsp90 can operate sequentially with Hsp90 selectively associating with H...

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Publicado en:J Biol Chem
Main Authors: Sun, Ming, Kotler, Judy L. M., Liu, Shanshan, Street, Timothy O.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484115/
https://ncbi.nlm.nih.gov/pubmed/30787103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007050
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