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Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α(1)-antitrypsin disposal

α(1)-Antitrypsin deficiency (AATD) is an inherited disease characterized by emphysema and liver disease. AATD is most often caused by a single amino acid substitution at position 342 in the mature protein, resulting in the Z mutation of the AAT gene (ZAAT). This substitution is associated with misfo...

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Foilsithe in:J Biol Chem
Main Authors: Khodayari, Nazli, Oshins, Regina, Alli, Abdel A., Tuna, Kubra M., Holliday, L. Shannon, Krotova, Karina, Brantly, Mark
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484112/
https://ncbi.nlm.nih.gov/pubmed/30833329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006142
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