A Novel Small Molecule Inhibits Intrahepatocellular Accumulation of Z-Variant Alpha 1-Antitrypsin In Vitro and In Vivo

Alpha 1-antitrypsin deficiency (AATD) is the most common genetic cause of liver disease in children and is associated with early-onset chronic liver disease in adults. AATD associated liver injury is caused by hepatotoxic retention of polymerized mutant alpha 1-antitrypsin molecules within the endop...

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Udgivet i:Cells
Main Authors: Zhang, Xiaojuan, Pham, Kien, Li, Danmeng, Schutte, Ryan J., Gonzalo, David Hernandez, Zhang, Penghui, Oshins, Regina, Tan, Weihong, Brantly, Mark, Liu, Chen, Ostrov, David A.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953066/
https://ncbi.nlm.nih.gov/pubmed/31817705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8121586
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