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Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway

There are a number of respiratory diseases characterized by the presence of excess neutrophil elastase (NE) activity in tissues, including cystic fibrosis and chronic obstructive pulmonary disease (COPD). NE is considered a primary contributor to disease development, but the precise mechanism has ye...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Krotova, Karina, Khodayari, Nazli, Oshins, Regina, Aslanidi, George, Brantly, Mark L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522083/
https://ncbi.nlm.nih.gov/pubmed/32981934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72667-3
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