Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity

Alpha-1 antitrypsin (AAT) deficiency–associated emphysema is largely attributed to insufficient inhibition of neutrophil elastase released from neutrophils. Correcting AAT levels using augmentation therapy only slows disease progression, and that suggests a more complex process of lung destruction....

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Krotova, Karina, Marek, George W., Wang, Rejean L., Aslanidi, George, Hoffman, Brad E., Khodayari, Nazli, Rouhani, Farshid N., Brantly, Mark L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800887/
https://ncbi.nlm.nih.gov/pubmed/28362108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0366OC
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