Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

RATIONALE: Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic dysfunction, and intracellular lipid accumulation, termed lipotoxicity. Diabetic hearts utilize fatty acids as a major energy source, which produces high levels of oxidative stress, thereby inducing mitochond...

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Veröffentlicht in:Circ Res
Hauptverfasser: Tong, Mingming, Saito, Toshiro, Zhai, Peiyong, Oka, Shin-ichi, Mizushima, Wataru, Nakamura, Michinari, Ikeda, Shohei, Shirakabe, Akihiro, Sadoshima, Junichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483841/
https://ncbi.nlm.nih.gov/pubmed/30786833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314607
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