Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma

The tumor microenvironment presents physical, immunologic, and metabolic barriers to durable immunotherapy responses. We have recently described roles for both T cell metabolic insufficiency as well as tumor hypoxia as inhibitory mechanisms that prevent T cell activity in murine tumors, but whether...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Najjar, Yana G., Menk, Ashley V., Sander, Cindy, Rao, Uma, Karunamurthy, Arivarasan, Bhatia, Roma, Zhai, Shuyan, Kirkwood, John M., Delgoffe, Greg M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483505/
https://ncbi.nlm.nih.gov/pubmed/30721155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124989
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