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Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma
The tumor microenvironment presents physical, immunologic, and metabolic barriers to durable immunotherapy responses. We have recently described roles for both T cell metabolic insufficiency as well as tumor hypoxia as inhibitory mechanisms that prevent T cell activity in murine tumors, but whether...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6483505/ https://ncbi.nlm.nih.gov/pubmed/30721155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124989 |
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