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Structure of the human ClC-1 chloride channel

ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) s...

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Bibliografiske detaljer
Udgivet i:PLoS Biol
Main Authors: Wang, Kaituo, Preisler, Sarah Spruce, Zhang, Liying, Cui, Yanxiang, Missel, Julie Winkel, Grønberg, Christina, Gotfryd, Kamil, Lindahl, Erik, Andersson, Magnus, Calloe, Kirstine, Egea, Pascal F., Klaerke, Dan Arne, Pusch, Michael, Pedersen, Per Amstrup, Zhou, Z. Hong, Gourdon, Pontus
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483157/
https://ncbi.nlm.nih.gov/pubmed/31022181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000218
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