Genetic inactivation of the phospholipase A(2) activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury

Peroxiredoxin 6 (Prdx6) is a multifunctional enzyme that serves important antioxidant roles by scavenging hydroperoxides and reducing peroxidized cell membranes. Prdx6 also plays a key role in cell signaling by activating the NADPH oxidase, type 2 (Nox2) through its acidic Ca(2+)-independent phospho...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Vázquez-Medina, José Pablo, Tao, Jian-Quin, Patel, Priyal, Bannitz-Fernandes, Renata, Dodia, Chandra, Sorokina, Elena M., Feinstein, Sheldon I., Chatterjee, Shampa, Fisher, Aron B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483013/
https://ncbi.nlm.nih.gov/pubmed/30702344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00344.2018
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