Transgenerational impact of maternal obesogenic diet on offspring bile acid homeostasis and nonalcoholic fatty liver disease

Studies show maternal obesity is a risk factor for metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) in offspring. Here we evaluated potential mechanisms underlying these phenotypes. Female C57Bl6 mice were fed chow or an obesogenic high-fat/high-sucrose (HF/HS) diet with subsequent ma...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Thompson, Michael D., Derse, Alaina, Ferey, Jeremie LA, Reid, Michaela, Xie, Yan, Christ, Miranda, Chatterjee, Deyali, Nguyen, Chau, Harasymowicz, Natalia, Guilak, Farshid, Moley, Kelle H., Davidson, Nicholas Oliver
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482665/
https://ncbi.nlm.nih.gov/pubmed/30860882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00474.2018
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