Maternal obesogenic diet enhances cholestatic liver disease in offspring

Human and animal model data show that maternal obesity promotes nonalcoholic fatty liver disease in offspring and alters bile acid (BA) homeostasis. Here we investigated whether offspring exposed to maternal obesogenic diets exhibited greater cholestatic injury. We fed female C57Bl6 mice conventiona...

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Auteurs principaux: Michael D. Thompson, Holly Hinrichs, Austin Faerber, Phillip I. Tarr, Nicholas O. Davidson
Format: Artigo
Langue:Inglês
Publié: Elsevier 2022-05-01
Collection:Journal of Lipid Research
Sujets:
bile acid metabolism
obesity
microbiome
liver
animal models
maternal high fat/high sucrose
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S0022227522000384
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