Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation

The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage–specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle sta...

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Publicat a:PLoS Biol
Autors principals: Ferreirós-Vidal, Isabel, Carroll, Thomas, Zhang, Tianyi, Lagani, Vincenzo, Ramirez, Ricardo N., Ing-Simmons, Elizabeth, Gómez-Valadés, Alicia G., Cooper, Lee, Liang, Ziwei, Papoutsoglou, Georgios, Dharmalingam, Gopuraja, Guo, Ya, Tarazona, Sonia, Fernandes, Sunjay J., Noori, Peri, Silberberg, Gilad, Fisher, Amanda G., Tsamardinos, Ioannis, Mortazavi, Ali, Lenhard, Boris, Conesa, Ana, Tegner, Jesper, Merkenschlager, Matthias, Gomez-Cabrero, David
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481923/
https://ncbi.nlm.nih.gov/pubmed/30978178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006506
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