Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation

The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage–specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle sta...

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Publicado no:PLoS Biol
Main Authors: Ferreirós-Vidal, Isabel, Carroll, Thomas, Zhang, Tianyi, Lagani, Vincenzo, Ramirez, Ricardo N., Ing-Simmons, Elizabeth, Gómez-Valadés, Alicia G., Cooper, Lee, Liang, Ziwei, Papoutsoglou, Georgios, Dharmalingam, Gopuraja, Guo, Ya, Tarazona, Sonia, Fernandes, Sunjay J., Noori, Peri, Silberberg, Gilad, Fisher, Amanda G., Tsamardinos, Ioannis, Mortazavi, Ali, Lenhard, Boris, Conesa, Ana, Tegner, Jesper, Merkenschlager, Matthias, Gomez-Cabrero, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481923/
https://ncbi.nlm.nih.gov/pubmed/30978178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006506
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