BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

Bromodomain-containing protein 9 (BRD9) is a recently identified subunit of SWI/SNF(BAF) chromatin remodeling complexes, yet its function is poorly understood. Here, using a genome-wide CRISPR-Cas9 screen, we show that BRD9 is a specific vulnerability in pediatric malignant rhabdoid tumors (RTs), wh...

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Vydáno v:Nat Commun
Hlavní autoři: Wang, Xiaofeng, Wang, Su, Troisi, Emma C., Howard, Thomas P., Haswell, Jeffrey R., Wolf, Bennett K., Hawk, William H., Ramos, Pilar, Oberlick, Elaine M., Tzvetkov, Evgeni P., Ross, Aaron, Vazquez, Francisca, Hahn, William C., Park, Peter J., Roberts, Charles W. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479050/
https://ncbi.nlm.nih.gov/pubmed/31015438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09891-7
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