BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

Bromodomain-containing protein 9 (BRD9) is a recently identified subunit of SWI/SNF(BAF) chromatin remodeling complexes, yet its function is poorly understood. Here, using a genome-wide CRISPR-Cas9 screen, we show that BRD9 is a specific vulnerability in pediatric malignant rhabdoid tumors (RTs), wh...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Xiaofeng, Wang, Su, Troisi, Emma C., Howard, Thomas P., Haswell, Jeffrey R., Wolf, Bennett K., Hawk, William H., Ramos, Pilar, Oberlick, Elaine M., Tzvetkov, Evgeni P., Ross, Aaron, Vazquez, Francisca, Hahn, William C., Park, Peter J., Roberts, Charles W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479050/
https://ncbi.nlm.nih.gov/pubmed/31015438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09891-7
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