SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

SMARCB1 (SNF5/INI1/BAF47), a core subunit of the SWI/SNF (BAF) chromatin remodeling complex(1,2), is inactivated in nearly all pediatric rhabdoid tumors(3–5). These aggressive cancers are among the most genomically stable(6–8), suggesting an epigenetic mechanism by which SMARCB1 loss drives transfor...

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Udgivet i:Nat Genet
Main Authors: Wang, Xiaofeng, Lee, Ryan S., Alver, Burak H., Haswell, Jeffrey R., Wang, Su, Mieczkowski, Jakub, Drier, Yotam, Gillespie, Shawn M., Archer, Tenley C., Wu, Jennifer N., Tzvetkov, Evgeni P., Troisi, Emma C., Pomeroy, Scott L., Biegel, Jaclyn A., Tolstorukov, Michael Y., Bernstein, Bradley E., Park, Peter J., Roberts, Charles W. M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5285474/
https://ncbi.nlm.nih.gov/pubmed/27941797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3746
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