SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

SMARCB1 (SNF5/INI1/BAF47), a core subunit of the SWI/SNF (BAF) chromatin remodeling complex(1,2), is inactivated in nearly all pediatric rhabdoid tumors(3–5). These aggressive cancers are among the most genomically stable(6–8), suggesting an epigenetic mechanism by which SMARCB1 loss drives transfor...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Genet
मुख्य लेखकों: Wang, Xiaofeng, Lee, Ryan S., Alver, Burak H., Haswell, Jeffrey R., Wang, Su, Mieczkowski, Jakub, Drier, Yotam, Gillespie, Shawn M., Archer, Tenley C., Wu, Jennifer N., Tzvetkov, Evgeni P., Troisi, Emma C., Pomeroy, Scott L., Biegel, Jaclyn A., Tolstorukov, Michael Y., Bernstein, Bradley E., Park, Peter J., Roberts, Charles W. M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5285474/
https://ncbi.nlm.nih.gov/pubmed/27941797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3746
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