A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins

There is an urgent need for affinity reagents that target phospho-modified sites on individual proteins; however, generating such reagents remains a significant challenge. Here, we describe a genetic selection strategy for routine laboratory isolation of phospho-specific designed ankyrin repeat prot...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Meksiriporn, Bunyarit, Ludwicki, Morgan B., Stephens, Erin A., Jiang, Allen, Lee, Hyeon-Cheol, Waraho-Zhmayev, Dujduan, Kummer, Lutz, Brandl, Fabian, Plückthun, Andreas, DeLisa, Matthew P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478843/
https://ncbi.nlm.nih.gov/pubmed/31015433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09854-y
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