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Twin-arginine translocase mutations that suppress folding quality control and permit export of misfolded substrate proteins

The bacterial twin-arginine translocation (Tat) pathway facilitates the transport of correctly folded proteins across the tightly sealed cytoplasmic membrane. Here, we report the isolation and characterization of suppressor mutations in the Tat translocase that allow export of misfolded proteins, wh...

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Detalhes bibliográficos
Main Authors: Rocco, Mark A., Waraho-Zhmayev, Dujduan, DeLisa, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421223/
https://ncbi.nlm.nih.gov/pubmed/22847444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210140109
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