Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish

Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of the (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays using various cancer cell lines, in vivo potency in prostate...

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Pubblicato in:Sci Rep
Autori principali: Xie, Yanqi, Kril, Liliia M., Yu, Tianxin, Zhang, Wen, Frasinyuk, Mykhaylo S., Bondarenko, Svitlana P., Kondratyuk, Kostyantyn M., Hausman, Elizabeth, Martin, Zachary M., Wyrebek, Przemyslaw P., Liu, Xifu, Deaciuc, Agripina, Dwoskin, Linda P., Chen, Jing, Zhu, Haining, Zhan, Chang-Guo, Sviripa, Vitaliy M., Blackburn, Jessica, Watt, David S., Liu, Chunming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478746/
https://ncbi.nlm.nih.gov/pubmed/31015569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42917-0
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