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An inner activation gate controls TMEM16F phospholipid scrambling

Transmembrane protein 16F (TMEM16F) is an enigmatic Ca(2+)-activated phospholipid scramblase (CaPLSase) that passively transports phospholipids down their chemical gradients and mediates blood coagulation, bone development and viral infection. Despite recent advances in the structure and function un...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Le, Trieu, Jia, Zhiguang, Le, Son C., Zhang, Yang, Chen, Jianhan, Yang, Huanghe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478717/
https://ncbi.nlm.nih.gov/pubmed/31015464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09778-7
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