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Molecular basis of PIP(2)-dependent regulation of the Ca(2+)-activated chloride channel TMEM16A
The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability, smooth muscle contraction, fluid secretion and gut motility. While opening of TMEM16A requires binding of intracellular Ca(2+), prolonged Ca(2+)-dependent activation results in channel dese...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6704070/ https://ncbi.nlm.nih.gov/pubmed/31434906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11784-8 |
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