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Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein. Here we detect antibodies to Streptococcus pyogenes Cas...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478683/ https://ncbi.nlm.nih.gov/pubmed/31015529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09693-x |
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