טוען...
Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein. Here we detect antibodies to Streptococcus pyogenes Cas...
שמור ב:
| הוצא לאור ב: | Nat Commun |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478683/ https://ncbi.nlm.nih.gov/pubmed/31015529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09693-x |
| תגים: |
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