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Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein. Here we detect antibodies to Streptococcus pyogenes Cas...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478683/ https://ncbi.nlm.nih.gov/pubmed/31015529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09693-x |
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