Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein. Here we detect antibodies to Streptococcus pyogenes Cas...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Ferdosi, Shayesteh R., Ewaisha, Radwa, Moghadam, Farzaneh, Krishna, Sri, Park, Jin G., Ebrahimkhani, Mo R., Kiani, Samira, Anderson, Karen S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478683/
https://ncbi.nlm.nih.gov/pubmed/31015529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09693-x
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