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RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36
DHX36 is a DEAH-box helicase that resolves parallel G-quadruplex structures formed in DNA and RNA. The recent co-crystal structure of DHX36 bound G4-DNA revealed an intimate contact, but did not address the role of ATP hydrolysis in G4 resolving activity. Here, we demonstrate that unlike on G4-DNA,...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478676/ https://ncbi.nlm.nih.gov/pubmed/31015431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09802-w |
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