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A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown. We report the structure of a bacterial RecQ DNA helicase bound to resolved G4 DNA. Unexpecte...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6180126/ https://ncbi.nlm.nih.gov/pubmed/30305632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06751-8 |
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