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A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

Homeostatic regulation of G-quadruplexes (G4s), four-stranded structures that can form in guanine-rich nucleic acids, requires G4 unwinding helicases. The mechanisms that mediate G4 unwinding remain unknown. We report the structure of a bacterial RecQ DNA helicase bound to resolved G4 DNA. Unexpecte...

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Udgivet i:Nat Commun
Main Authors: Voter, Andrew F., Qiu, Yupeng, Tippana, Ramreddy, Myong, Sua, Keck, James L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180126/
https://ncbi.nlm.nih.gov/pubmed/30305632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06751-8
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