The HRDC domain oppositely modulates the unwinding activity of E. coli RecQ helicase on duplex DNA and G-quadruplex

RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domai...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Teng, Fang-Yuan, Wang, Ting-Ting, Guo, Hai-Lei, Xin, Ben-Ge, Sun, Bo, Dou, Shuo-Xing, Xi, Xu-Guang, Hou, Xi-Miao
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762929/
https://ncbi.nlm.nih.gov/pubmed/33454004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015492
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