The HRDC domain oppositely modulates the unwinding activity of E. coli RecQ helicase on duplex DNA and G-quadruplex

RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domai...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Teng, Fang-Yuan, Wang, Ting-Ting, Guo, Hai-Lei, Xin, Ben-Ge, Sun, Bo, Dou, Shuo-Xing, Xi, Xu-Guang, Hou, Xi-Miao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762929/
https://ncbi.nlm.nih.gov/pubmed/33454004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015492
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