The HRDC domain oppositely modulates the unwinding activity of E. coli RecQ helicase on duplex DNA and G-quadruplex

RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domai...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Teng, Fang-Yuan, Wang, Ting-Ting, Guo, Hai-Lei, Xin, Ben-Ge, Sun, Bo, Dou, Shuo-Xing, Xi, Xu-Guang, Hou, Xi-Miao
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762929/
https://ncbi.nlm.nih.gov/pubmed/33454004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015492
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