The HRDC domain oppositely modulates the unwinding activity of E. coli RecQ helicase on duplex DNA and G-quadruplex

RecQ family helicases are highly conserved from bacteria to humans and have essential roles in maintaining genome stability. Mutations in three human RecQ helicases cause severe diseases with the main features of premature aging and cancer predisposition. Most RecQ helicases shared a conserved domai...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Teng, Fang-Yuan, Wang, Ting-Ting, Guo, Hai-Lei, Xin, Ben-Ge, Sun, Bo, Dou, Shuo-Xing, Xi, Xu-Guang, Hou, Xi-Miao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Molecular Biophysics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762929/
https://ncbi.nlm.nih.gov/pubmed/33454004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015492
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