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Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36
Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than what most polymerases can exert(1,2). Eukaryotic cells host numerous helicases capable of unfoldin...
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| Vydáno v: | Nature |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6261253/ https://ncbi.nlm.nih.gov/pubmed/29899445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0209-9 |
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