Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase

The unwinding of nucleic acid secondary structures within cells is crucial to maintain genomic integrity and prevent abortive transcription and translation initiation. DHX36, also known as RHAU or G4R1, is a DEAH-box ATP-dependent helicase highly specific for DNA and RNA G-quadruplexes (G4s). A fund...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Chen, Michael C., Murat, Pierre, Abecassis, Keren, Ferré-D'Amaré, Adrian R., Balasubramanian, Shankar
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344499/
https://ncbi.nlm.nih.gov/pubmed/25653156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv051
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