The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

Evidence has emerged that the failing heart increases utilization of ketone bodies. We sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing the ketone body 3-hydroxybutyrate (3OHB) in the heart exhibited worsened heart failure in response to fasting or a pres...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Horton, Julie L., Davidson, Michael T., Kurishima, Clara, Vega, Rick B., Powers, Jeffery C., Matsuura, Timothy R., Petucci, Christopher, Lewandowski, E. Douglas, Crawford, Peter A., Muoio, Deborah M., Recchia, Fabio A., Kelly, Daniel P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478419/
https://ncbi.nlm.nih.gov/pubmed/30668551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124079
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